Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney.
نویسندگان
چکیده
منابع مشابه
Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney.
1. We have examined whether an increase of renal vascular resistance is generally accompanied by an inhibition of renin secretion. The effects of vasoconstriction produced by angiotensin II (Ang II), arginine-vasopressin (AVP), and potassium (KCl) depolarization on vascular resistance and on renin release from isolated rat kidneys perfused at constant pressure of 100 mmHg were investigated. 2. ...
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To avoid complicating systemic effects, the influence of adrenergic hormones on renin secretion was examined in the isolated rat kidney perfused with Krebs-dextran solution at a constant mean pressure and flow rate. Isoproterenol and glucagon produced a consistent increase in renin secretion without a change in perfusion pressure and flow. Similarly the increase in renin secretion with norepine...
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We investigated the relevance of anions for the regulation of renin secretion from the kidneys. For this purpose we measured renin release from isolated rat kidneys that were perfused with medium containing either 120 mmol/l (normal) chloride or 95 mmol/l of isethionate, acetate, or nitrate anions in exchange for equimolar amounts of chloride. Lowering the extracellular chloride concentration b...
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1. In the isolated rat kidney, perfused at constant pressure with a medium free from renin substrate, addition of angiotensin I to the perfusate decreases renal 'plasma' flow. 2. A peptide inhibitor, SQ 20881, of converting enzyme reduces the vasoconstrictor effect of angiotensin I up to a maximum of 87%, the degree of inhibition being dose-dependent. 3. The molar ratio of equi-effective doses ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1991
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1991.sp018761